Pbx4, a new Pbx family member on mouse chromosome 8, is expressed during spermatogenesis
نویسندگان
چکیده
Members of the Pbx family are involved in a diverse range of developmental processes including axial patterning and organogenesis. Pbx functions are in part mediated by the interaction of Pbx proteins with members of the Hox and Meis/Prep families. We have identified a fourth mammalian Pbx family member. Pbx4 in the mouse and PBX4 in humans are located on chromosome 8 and chromosome 19, respectively. Pbx4 expression is confined to the testis, especially to spermatocytes in the pachytene stage of the first meiotic prophase.
منابع مشابه
Pbx and Meis form dimeric and trimeric complexes with Hox proteins in vitro and these complexes are thought to modulate Hox activity, primarily by conferring high-specificity
Vertebrate hox genes, like their Drosophila counterparts the HOM-C genes, play essential roles during embryogenesis. For instance, their expression in overlapping domains along the anteroposterior (AP) axis provides a ‘hox code’ that specifies AP positional identity, and changes in hox gene expression lead to homeotic transformations in the AP axis, wherein anterior structures acquire the chara...
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ورودعنوان ژورنال:
- Mechanisms of Development
دوره 103 شماره
صفحات -
تاریخ انتشار 2001